How frequently do large bowel diverticula perforate? An incidence and cross-sectional study
| Autor: | Nicholas E. Day, Andrew Hart, Kennedy Hj, W S L Stebbings |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Perforation (oil well) Bowel diverticula Diverticulum Colon digestive system Risk Factors medicine Cecal Diseases Humans Diverticulum (mollusc) Risk factor Colonic disease Aged Aged 80 and over Hepatology business.industry Incidence (epidemiology) Incidence Anti-Inflammatory Agents Non-Steroidal Gastroenterology Middle Aged digestive system diseases Surgery Analgesics Opioid Diverticulum Cross-Sectional Studies England Intestinal Perforation Etiology Female Radiology business |
| Zdroj: | European journal of gastroenterologyhepatology. 12(6) |
| ISSN: | 0954-691X |
| Popis: | The aetiology of perforation of large bowel diverticula is poorly understood and a case-control study is required to identify the causes. Before such a study can be attempted, the incidence must be determined and groups at particular risk identified. Cases of perforated large bowel diverticula living in the Norwich postal code region treated between 1995 and 1997 were identified. Fifty-eight cases presented in a population of 531 241. The incidence was 4.0 cases per 100,000 per year, increased with age and was higher in men than women (5.8 vs 3.1). The most frequently used drugs were non-steroidal anti-inflammatory drugs (NSAIDs) (29%) and opiate analgesics (26% of cases). This is the first report of the incidence of perforated diverticular disease and allows a calculation of the population size needed to recruit sufficient cases for an aetiological investigation. The differences in incidence between genders should prompt a search for factors which differ between the sexes such as diet. NSAIDs are a known risk factor, although the data show that opiate analgesics should be investigated. |
| Databáze: | OpenAIRE |
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