Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study
| Autor: | Madeleine Dólleman, F. Yarde, Frank J.M. Broekmans, Erik A. H. Knauff, Marinus J.C. Eijkemans, Marlies Voorhuis |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Anti-Mullerian Hormone endocrine system medicine.medical_specialty Pregnancy Rate media_common.quotation_subject Physiology Fertility Biology Follicle-stimulating hormone Basal (phylogenetics) Young Adult Pregnancy medicine Humans Ovarian reserve Menstrual cycle Menstrual Cycle media_common Gynecology Infant Newborn Pregnancy Outcome Obstetrics and Gynecology medicine.disease Prognosis Menopause Reproductive Medicine Infertility Female Follicle Stimulating Hormone Live birth Biomarkers Cohort study Follow-Up Studies |
| Zdroj: | Fertility and sterility. 100(3) |
| ISSN: | 1556-5653 |
| Popis: | Objective To investigate the role of serum antimullerian hormone (AMH) as a predictor of live birth and reproductive stage in subfertile women with elevated basal FSH levels. Design A prospective observational cohort study conducted between February 2005 and June 2009. Setting Tertiary fertility center. Patient(s) Subfertile women with [1] a regular menstrual cycle (mean cycle length 25–35 days); [2] basal FSH concentrations ≥12.3 IU/L; and [3] younger than 40 years (n = 96). Intervention(s) None. Main Outcome Measure(s) Live birth and reproductive stage according to the Stages of Reproductive Aging Workshop. Result(s) A cumulative live birth rate of 63.5% was observed during a median follow-up of 3.3 years (n = 85). The AMH level was significantly associated with live birth. There was evidence of a nonlinear prediction pattern, with an increase in chances of live birth until an AMH level of 1 μg/L. Other ovarian reserve tests and chronological age appeared of limited value in predicting live birth. In addition, AMH was significantly associated with the timing of reproductive stages (n = 68) (i.e., the occurrence of menopausal transition or menopause during follow-up). Conclusion(s) The present findings suggest applicability of AMH determination as a marker for actual fertility in subfertile women with elevated basal FSH levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|