Interleukin-8 induction and adhesion of the coccoid form of Helicobacter pylori
| Autor: | Hayato Kawakami, Hiroshi Hirano, Minoru Fukada, Haruhiko Taguchi, Takako Osaki, Hiroyuki Yamaguchi, Shigeru Kamiya |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
Lipopolysaccharide medicine.drug_class medicine.medical_treatment Monoclonal antibody Microbiology Bacterial Adhesion Flow cytometry chemistry.chemical_compound Tumor Cells Cultured medicine Humans Secretion Anaerobiosis Interleukin 8 Helicobacter pylori biology medicine.diagnostic_test Interleukin-8 General Medicine Adhesion Flow Cytometry biology.organism_classification digestive system diseases Cytokine chemistry Gastric Mucosa Microscopy Electron Scanning |
| Zdroj: | Journal of Medical Microbiology. 51:295-299 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/0022-1317-51-4-295 |
| Popis: | To determine the pathological significance of the coccoid form of Helicobacter pylori, its adhesion to and induction of secretion of interleukin-8 (IL-8) by gastric epithelial (MKN45) cells were studied. By flow cytometry, the adhesion of the coccoid form to MKN45 cells was significantly lower than that of the helical form. The monoclonal antibody A20 recognising lipopolysaccharide of H. pylori inhibited the adhesion of the coccoid form to MKN45 cells as much as that of the helical form. There was significantly lower induction of IL-8 secretion by MKN45 cells exposed to the coccoid form (two of four strains) as compared with the helical form. |
| Databáze: | OpenAIRE |
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