Minimal effects from a single exposure to sevoflurane in adult male and female Sprague-Dawley rats
| Autor: | Timothy J. Flanigan, Sherry A. Ferguson, Charles D. Law |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Spatial Learning Water maze 010501 environmental sciences Motor Activity Toxicology 01 natural sciences Sevoflurane Body Temperature Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cognition Postoperative Complications Developmental Neuroscience Heart Rate Heart rate medicine Sprague dawley rats Animals 0105 earth and related environmental sciences Oxygen saturation (medicine) Spatial Memory business.industry Body Weight Recognition Psychology Organ Size medicine.disease Motor coordination Rats Oxygen Anesthesia Anesthetics Inhalation Female business Postoperative cognitive dysfunction 030217 neurology & neurosurgery Psychomotor Performance medicine.drug |
| Zdroj: | Neurotoxicology and teratology. 84 |
| ISSN: | 1872-9738 |
| Popis: | Many people undergo procedures requiring general anesthesia each day and adverse cognitive effects have been reported in response to that anesthesia. Postoperative Cognitive Dysfunction (POCD) may occur in as many as 80% of adults during the first post-surgical week and can have lasting effects. Here, the cognitive and motor effects of sevoflurane exposure in Sprague-Dawley rats was examined along with body weights, blood oxygen saturation, heart rate, and body temperature. Male and female rats were exposed to 2.5% sevoflurane or medical grade air for one hour at postnatal day 115. Beginning the following day, rats began a series of behavioral tests examining locomotor activity, motor coordination, novel object recognition, and spatial learning and memory in a water maze. Blood oxygen saturation, heart rate, and body temperature were not affected by the sevoflurane exposure. A slight effect on locomotor activity was detected, but no effects on motor coordination, novel object recognition, or spatial learning and memory were observed. Brain weights following behavioral testing did not differ. The results reported here along with existing literature suggest sevoflurane is largely without effects on later cognition in adult rodents when exposure is of a relatively short duration and at a relatively low concentration. |
| Databáze: | OpenAIRE |
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