Anatomical and Functional Changes of the Retina and the Choroid after Resolved Chronic CSCR

Autor: Emanuele Doronzo, Marta Di Nicola, Luca Di Antonio, Rodolfo Mastropasqua, Emanuele Erroi, Lisa Toto, Federica Evangelista, Cesare Mariotti, Rossella D'Aloisio, Giuseppe Di Martino
Jazyk: angličtina
Rok vydání: 2019
Předmět:
medicine.medical_specialty
Visual acuity
Choriocapillaris density
genetic structures
chronic central serous chorioretinopathy
lcsh:Medicine
subfoveal choroidal thickness
optical coherence tomography angiography
superficial capillary plexus density
Chronic central serous chorioretinopathy
eplerenone therapy
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Foveal
Ophthalmology
Superficial capillary plexus density
0502 economics and business
medicine
Retina
business.industry
lcsh:R
05 social sciences
Significant difference
Retinal
General Medicine
Eplerenone therapy
Optical coherence tomography angiography
Subfoveal choroidal thickness
eye diseases
Eplerenone
medicine.anatomical_structure
chemistry
choriocapillaris density
030221 ophthalmology & optometry
050211 marketing
Choroid
sense organs
medicine.symptom
business
medicine.drug
Zdroj: Journal of Clinical Medicine
Volume 8
Issue 4
Journal of Clinical Medicine, Vol 8, Iss 4, p 474 (2019)
ISSN: 2077-0383
DOI: 10.3390/jcm8040474
Popis: Background: To investigate anatomical/functional changes after oral eplerenone therapy for chronic central serous chorioretinopathy (CCSC) in successfully treated eyes and fellow eyes and assess timing of foveal subretinal fluid (SRF) resolution. Methods: Twenty-one eyes of 21 patients suffering from CCSC with monolateral foveal SRF successfully treated with oral eplerenone were enrolled in this retrospective study (group 1). The fellow eyes (21 eyes
group 2), healthy or affected by CCSC, without foveal SRF were considered in the analysis. A control healthy group was enrolled as well (healthy controls
n = 21). Main outcome measures during follow-up included changes of best corrected visual acuity (BCVA, logMAR), central macular thickness (CMT
µ
m), SRF (µ
m), subfoveal choroidal thickness (SFCT
m), superficial capillary plexus density (SCPD, %), deep capillary plexus density (DCPD, %), and choriocapillaris density (CCD, %) and percentage of eyes showing foveal SRF resolution at different time points. Results: Functional and anatomical parameters significantly improved during the study in group 1. BCVA increased significantly (p <
0.001), while CMT, SFCT, and SRF decreased significantly (p <
0.001
p <
0.001, and p = 0.037, respectively). SCPD, DCPD, and CCD did not show any statistically significant difference during follow-up. In 71.4% of eyes, resolution of SRF was observed within 60 days and in the remaining 28.6%, at 120 days. In fellow eyes, SFCT decreased significantly (p <
0.001), whilst all other parameters did not modify. Conclusions: Eplerenone treatment in chronic CSCR potentially improves recovery of retinal and choroidal morphology as well as visual acuity gain. A complete resolution of foveal SRF was observed in all eyes during a 4-month follow-up, with most eyes healing at 2 months.
Databáze: OpenAIRE
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