Population genetics of the Malmö polymorphism of coagulation factor IX
| Autor: | Anders Wallmark, John Bosco, Glenna Kunkel, Rolf Ljung, John B. Graham, Inga Marie Nilsson, Hassan Mouhli |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Asia Genotype Population Ethnic group Population genetics Black People Skin Pigmentation Factor IX Mediterranean Islands Africa Northern Gene Frequency Polymorphism (computer science) Genetics Humans East Asia Allele education Allele frequency Genetics (clinical) Alleles Sweden education.field_of_study Polymorphism Genetic Europe Geography Genetics Population Female Demography |
| Zdroj: | Human heredity. 41(6) |
| ISSN: | 0001-5652 |
| Popis: | The distribution of 1,198 Malmo alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmo B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia, Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans. Assuming selective neutrality, the data are consistent with the European origin of the ‘B’ allele when the population was small and outward spread. |
| Databáze: | OpenAIRE |
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