Effect of raised plasma beta endorphin concentrations on peripheral pain and angina thresholds in patients with stable angina
| Autor: | D C Russell, A Iranmanesh, N F Jarmukli, J Ahn |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Pain Threshold medicine.drug_class Narcotic Antagonists (+)-Naloxone Dexamethasone Angina Pectoris Angina chemistry.chemical_compound Threshold of pain medicine Humans Opioid peptide Glucocorticoids Naloxone business.industry beta-Endorphin Middle Aged medicine.disease Stimulation Chemical Ketoconazole Opioid chemistry Pituitary Gland Anesthesia Papers Linear Models Corticosteroid Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Heart. 82:204-209 |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/hrt.82.2.204 |
| Popis: | OBJECTIVE—To determine whether changes in plasma concentrations of β endorphins alter angina threshold and peripheral pain threshold in patients with stable angina. DESIGN—Latin square design comparison of angina thresholds by exercise treadmill test and peripheral pain thresholds using a radiant heat source in eight patients with stable angina under control conditions, after stimulation of pituitary β endorphin release by ketoconazole, after suppression of pituitary β endorphin release by dexamethasone, and after blockade of opioid receptors by intravenous naloxone. RESULTS—An approximately fivefold increase in circulating concentrations of β endorphins was found after administration of ketoconazole (mean (SEM): 13.9 (1.2) v 73.8 (6.2) pg/ml; p |
| Databáze: | OpenAIRE |
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