Role of Kupffer cells and suppressor T cells in the graft versus host reaction after intrahepatic lymphoid tissue implantation
| Autor: | Rosy Eloy, Guy Clendinnen, Dominique Vuitton, Grenier Jf |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Kupffer Cells
T-Lymphocytes Phagocytosis medicine.medical_treatment Immunology Graft versus host reaction Biology law.invention Graft vs Host Reaction law medicine Animals Mortality Immunosuppression Therapy Immunosuppression Rats Blockade Thymectomy Lymphatic system Liver Cancer research Suppressor Lymph Nodes Lymph Spleen |
| Zdroj: | Cellular Immunology. 34:138-145 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/0008-8749(77)90236-2 |
| Popis: | Semiallogeneic lymph nodes were implanted into the livers of rats to study the roles of Kupffer cells and suppressor T cells in immunosuppression during the graft versus host (GVH) reaction. Two experimental procedures have been used to impair the function of both types of cells separately, namely, blockade of phagocytosis by a colloidal substrate at the time of antigen recognition or adult thymectomy 10 weeks before the induction of the GVH reaction. The results suggest that a subpopulation of the recipient's short-lived T lymphocytes is involved in the immunosuppressive function of the intact liver. In contrast it appears that Kupffer cells are not an essential component of the protective mechanisms of the liver. |
| Databáze: | OpenAIRE |
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