Autor: |
Tran Chinh Viet, Charles R. Kissinger, Daniel A. Norris, Ruhi Kamran, Amit M. Shah, Jingjing Zhao, Yuefen Zhou, Rupal Patel, Matthew Lardy, Darian M. Bartkowski, Richard E. Showalter, Stephen E. Webber, Laurie A. LeBrun, Mei Tsan, Douglas E. Murphy, Sun Hee Kim, Maria V. Sergeeva, Leo Kirkovsky, Martin T. Tran, Thomas G. Nolan, Qing Han, Frank Ruebsam, Lian-Sheng Li, Peter S. Dragovich |
Rok vydání: |
2008 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 18:3616-3621 |
ISSN: |
0960-894X |
Popis: |
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and replicon assays (IC(50) (1b)10nM; EC(50) (1b)=12 nM) as well as good stability towards human liver microsomes (HLM t(1/2)60 min). |
Databáze: |
OpenAIRE |
Externí odkaz: |
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