Assessment of soluble platelet CD40L and CD62P during the preparation process and the storage of apheresis platelet concentrates: Absence of factors related to donors and donations
| Autor: | Patricia Chavarin, Sandrine Laradi, Caroline Sut, Charles-Antoine Arthaud, Hind Hamzeh-Cognasse, Olivier Garraud, Marie-Ange Eyraud, Sofiane Tariket, Jocelyne Fagan, Chaker Aloui, Fabrice Cognasse |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Platelets
Male Time Factors CD40 Ligand Clinical Biochemistry Blood Donors Platelet Transfusion 030204 cardiovascular system & hematology Pharmacology 03 medical and health sciences 0302 clinical medicine Humans Platelet Platelet concentrate Platelet activation Biological response modifiers Soluble cd40l CD40 biology Chemistry Plateletpheresis Biochemistry (medical) Hematology Platelet Activation P-Selectin Apheresis Blood Preservation biology.protein Female 030215 immunology |
| Zdroj: | Transfusion Clinique et Biologique. 25:192-196 |
| ISSN: | 1246-7820 |
| Popis: | Platelet transfusions may be associated with certain adverse effects in recipients, potentially caused by the presence of biological response modifiers contained in the platelet concentrates. The aim of this study is to identify the parameters that reflect platelet activation during both the preparation process and the storage of platelet concentrates. A total of 3,949apheresis platelet concentrate samples were studied with regard to parameters related to the donor as well as to the preparation process and their storage. Key glycoproteins characteristic of platelet activation, i.e. soluble CD40L and CD62P, were quantified in platelet concentrate supernatants on completion of their processing and during storage, using Luminex technology. We observed an increase in soluble factors over time. However, the different parameters studied in connection either with the donors or with the donations, such as (i) donor gender, (ii) donor blood group, (iii) time of collection and (iv) type of apheresis separator, do not seem to have any effect on platelet activation or the release of soluble CD40L and CD62P. |
| Databáze: | OpenAIRE |
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