The origin and evolution of cell types
| Autor: | Manfred Dietrich Laubichler, Jacob M. Musser, Stefanie Widder, Connie Cepko, Mihaela Pavlicev, Aviv Bergman, Clare V. H. Baker, Douglas H. Erwin, Detlev Arendt, Günter P. Wagner, Gerhard Schlosser |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell type Human evolutionary genetics Cells Cellular differentiation Gene regulatory network Cell Differentiation Biology Biological Evolution 03 medical and health sciences Multicellular organism 030104 developmental biology Phylogenetics Evolutionary biology Genetics Animals Humans Epistasis Cell Lineage Gene Regulatory Networks Evolutionary dynamics Molecular Biology Phylogeny Genetics (clinical) |
| Zdroj: | Nature Reviews Genetics. 17:744-757 |
| ISSN: | 1471-0064 1471-0056 |
| Popis: | Cell types are the basic building blocks of multicellular organisms and are extensively diversified in animals. Despite recent advances in characterizing cell types, classification schemes remain ambiguous. We propose an evolutionary definition of a cell type that allows cell types to be delineated and compared within and between species. Key to cell type identity are evolutionary changes in the 'core regulatory complex' (CoRC) of transcription factors, that make emergent sister cell types distinct, enable their independent evolution and regulate cell type-specific traits termed apomeres. We discuss the distinction between developmental and evolutionary lineages, and present a roadmap for future research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink