Establishing a Framework for Gathering Structural and Social Determinants of Health in Alzheimer’s Disease Research Centers
| Autor: | Shana D Stites, Sharnita Midgett, Dawn Mechanic-Hamilton, Megan Zuelsdorff, Crystal M Glover, David X Marquez, Joyce E Balls-Berry, Marissa L Streitz, Ganesh Babulal, Jean-Francois Trani, J Neil Henderson, Lisa L Barnes, Jason Karlawish, Dave A Wolk |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Gerontologist |
| ISSN: | 1758-5341 0016-9013 |
| Popis: | Structural and social determinants of health (SSDoH) are environmental conditions in which individuals are born, live, learn, work, play, worship, and age that affect health, functioning, and quality-of-life outcomes across the life course. Growing evidence suggests that SSDoH can help to explain heterogeneity in outcomes in Alzheimer’s disease and Alzheimer’s disease and related dementias (AD/ADRD) research and clinical practice. The National Institute on Aging has prioritized collecting SSDoH data to elucidate disease mechanisms and aid discovery of disease-modifying treatments. However, a major nexus of AD/ADRD research, the national network of Alzheimer’s Disease Research Centers (ADRCs), collects few SSDoH data. We describe a framework for feasibly gathering and modeling SSDoH data across ADRCs. We lay out key constructs, their measures, and empirical evidence for their importance in elucidating disease and prevention mechanisms. Toward a goal of translation, the framework proposes a modular structure with a core set of measures and options for adjunctive modules. We describe considerations for measuring SSDoH in existing geographically and culturally diverse research cohorts. We also outline a rationale for universal implementation of a set of SSDoH measures and juxtapose the approach with alternatives aimed at collecting SSDoH data. |
| Databáze: | OpenAIRE |
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