Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

Autor:	Andrea Termine, Claudia Strafella, Giulia Campoli, Gianfranco Spalletta, Carlo Caltagirone, Valerio Caputo, Carlo Fabrizio, Raffaella Cascella, Laura Petrosini, Michele Ragazzo, Clelia Pellicano, Stefania Zampatti, Emiliano Giardina
Rok vydání:	2021
Předmět:	pharmacogenomic software business.industry neuroPGx Medicine (miscellaneous) Single-nucleotide polymorphism Computational biology Precision medicine Article OpenArray Clinical Practice Pharmacogenomics Medicine Web application Routine clinical practice Dosage adjustment business Pharmacogenetics
Zdroj:	Journal of Personalized Medicine Volume 11 Issue 9 Journal of Personalized Medicine, Vol 11, Iss 851, p 851 (2021)
ISSN:	2075-4426
Popis:	The management of neuropsychiatric disorders involves different pharmacological treatments. In order to perform efficacious drug treatments, the metabolism of CYP genes can help to foresee potential drug–drug interactions. The NeuroPGx software is an open-source web-based tool for genotype/diplotype/phenotype interpretation for neuropharmacogenomic purposes. The software provides information about: (i) the genotypes of evaluated SNPs (single nucleotide polymorphisms) (ii) the main diplotypes in CYP genes and corresponding metabolization phenotypes (iii) the list of neuropsychiatric drugs with recommended dosage adjustment (according to CPIC and DPWG guidelines) (iv) the list of possible (rare) diplotypes and corresponding metabolization phenotypes. The combined application of NeuroPGx software to the OpenArray technology results in an easy, quick, and highly automated device ready to be used in routine clinical practice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f458b3933541fdb95cd9d4037b9b024 https://doi.org/10.3390/jpm11090851 Zobrazit plný text záznamu