Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines
| Autor: | Joaquín Manjarrez, Juan Calleja-Castillo, Gabriel Morales-Espinoza, María Eugenia Hernández, Lenin Pavón, Marco A. Velasco-Velázquez, Lucinda Aguirre-Cruz, Dora Luz de la Cruz-Aguilera, Julia Moreno-Aguilar |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Deep brain stimulation Article Subject medicine.medical_treatment Deep Brain Stimulation Immunology Interleukin-1beta Hypothalamus Systemic inflammation Proinflammatory cytokine chemistry.chemical_compound Interferon-gamma Corticosterone Internal medicine medicine Immunology and Allergy Animals Interleukin 6 biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha General Medicine Rats Endocrinology chemistry Circulatory system biology.protein Cytokines Tumor necrosis factor alpha medicine.symptom Inflammation Mediators business lcsh:RC581-607 Research Article |
| Zdroj: | Clinical and Developmental Immunology, Vol 2013 (2013) Clinical and Developmental Immunology |
| ISSN: | 1740-2530 1740-2522 |
| Popis: | Deep brain stimulation (DBS) is a therapeutic option for several diseases, but its effects on HPA axis activity and systemic inflammation are unknown. This study aimed to detect circulatory variations of corticosterone and cytokines levels in Wistar rats, after 21 days of DBS-at the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl), unilateral cervical vagotomy (UCVgX), or UCVgX plus DBS. We included the respective control (C) and sham (S) groups (n=6rats per group). DBS treated rats had higher levels of TNF-α(120%;P<0.01) and IFN-γ(305%;P<0.001) but lower corticosterone concentration (48%;P<0.001) than C and S. UCVgX animals showed increased corticosterone levels (154%;P<0.001) versus C and S. UCVgX plus DBS increased IL-1β(402%;P<0.001), IL-6 (160%;P<0.001), and corsticosterone (178%;P<0.001versus 48%;P<0.001) compared with the C and S groups. Chronic DBS at VMHvl induced a systemic inflammatory response accompanied by a decrease of HPA axis function. UCVgX rats experienced HPA axis hyperactivity as result of vagus nerve injury; however, DBS was unable to block the HPA axis hyperactivity induced by unilateral cervical vagotomy. Further studies are necessary to explore these findings and their clinical implication. |
| Databáze: | OpenAIRE |
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