Intracerebral hemorrhage after thrombolytic therapy in acute ischemic stroke patients with renal dysfunction
| Autor: | Tzu Hao Chao, Jiann-Der Lee, Tsong Hai Lee, Yeu Jhy Chang, Ting Chun Lin, Chi-Hung Liu, Chien Hung Chang, Kuo Lun Hung, Ting-Yu Chang, Yao Shieh |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Treatment outcome Tissue plasminogen activator Brain Ischemia Fibrinolytic Agents Internal medicine medicine Humans Thrombolytic Therapy cardiovascular diseases Acute ischemic stroke Aged Cerebral Hemorrhage Intracerebral hemorrhage Aged 80 and over business.industry Thrombolysis Middle Aged medicine.disease nervous system diseases Stroke Treatment Outcome Neurology Tissue Plasminogen Activator Cardiology Female Kidney Diseases Neurology (clinical) Medical emergency Complication business medicine.drug Glomerular Filtration Rate |
| Zdroj: | European neurology. 70(5-6) |
| ISSN: | 1421-9913 |
| Popis: | Purpose: One complication of thrombolysis is intracranial hemorrhage (ICH). We investigated whether treatment with tissue plasminogen activator (t-PA) for ischemic infarction results in a higher risk of ICH in patients with kidney dysfunction, who are predisposed to treatment complications due to their bleeding tendency. Methods: A total of 297 patients given thrombolytic therapy for ischemic stroke were classified into 2 groups on the basis of their estimated renal glomerular filtration rate (eGFR). The outcome measures included the incidence of ICH and modified Rankin scale scores at 1 month and 1 year. Results: ICH was more common in the renal dysfunction group (23 vs. 12.5%). Nevertheless, multivariate logistic regression showed that the odds of ICH were not high in the group with low eGFR. Also, eGFR values 2 did not predict the odds for functional dependence or death at 1 month and 1 year. Conclusion: After adjusting for confounding factors, the odds ratio for ICH was not higher in intravenous t-PA-treated stroke patients with renal dysfunction. A trend to the occurrence of ICH among these patients, however, was noted. Renal dysfunction does not predict the odds for functional dependence or death at 1 month and 1 year. |
| Databáze: | OpenAIRE |
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