Anti-hepatitis B core antibody is not required for prevaccination screening in healthcare workers
| Autor: | Mi Suk Lee, Seok Ho Dong, Jae Young Jang, Kyung Yup Kim, Hyo Jong Kim, Young Hwangbo, Byung-Ho Kim, Jae-Jun Shim, Young Woon Chang, Rin Chang, Hee-Kyung Chun |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Health Personnel medicine.disease_cause Serology Young Adult Blood serum Antigen Prevalence Humans Medicine Hepatitis B Vaccines Prospective Studies Hepatitis B Antibodies Seroconversion Hepatitis B virus General Veterinary General Immunology and Microbiology biology business.industry Vaccination Age Factors Public Health Environmental and Occupational Health virus diseases Odds ratio Middle Aged Hepatitis B Hepatitis B Core Antigens digestive system diseases Infectious Diseases Case-Control Studies Antibody Formation DNA Viral Multivariate Analysis Immunology biology.protein Molecular Medicine Female Antibody business |
| Zdroj: | Vaccine. 29:1721-1726 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2010.11.044 |
| Popis: | Vaccination against hepatitis B virus (HBV) is recommended for health care workers (HCWs), but it is not clear whether HBV vaccination is required for HCWs who have isolated antibody to hepatitis B core antigen (anti-HBc), or whether prevaccination screening for anti-HBc is needed in HCWs. Among 1812 HCWs, subjects with isolated anti-HBc and those with no HBV markers (control) were screened. The anamnestic response (antibody to hepatitis B surface antigen over 50 mIU/mL after the first vaccine injection) was compared prospectively between the two groups. The prevalence of isolated anti-HBc was 2.3%. Their anamnestic response was lower than that of controls (27.5% vs. 46.9%, P = 0.020). The subjects who had isolated anti-HBc were older and predominantly male, compared with the controls. Multivariate analysis revealed that age (odds ratio [OR], 0.67; confidence interval [CI], 0.51–0.90) and prior vaccination (OR, 3.36; CI, 2.04–5.54) were independent predictors of the anamnestic response, regardless of the anti-HBc status. Serum HBV DNA was not detected in any subject. Anti-HBs seroconversion was achieved in most of the anti-HBc-positive subjects after full vaccination, and the rate was comparable with controls (89.5% vs. 96.6%, P = 0.067). Isolated anti-HBc-positive HCWs are rare and most of them respond to vaccination. Anti-HBc testing is not a prerequisite for vaccination. This serology suggests a loss of acquired anti-HBs rather than occult HBV infection. Their reduced immunity to vaccination may be related to old age. |
| Databáze: | OpenAIRE |
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