Malignant stroke in an adolescent with a homozygous MTHFR 677CT mutation and intake of hormonal contraceptives
| Autor: | Klaus Pfurtscheller, Barbara Plecko, Beatrice Senning, Michael Novak, Gerfried Zobel, Heike Bernhard, Wolfgang Muntean |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pediatrics
medicine.medical_specialty Heart disease Adolescent Population Contraceptives Oral Hormonal Fatal Outcome medicine Humans education Stroke Homocysteine Coagulation Disorder Methylenetetrahydrofolate Reductase (NADPH2) education.field_of_study biology business.industry Infarction Middle Cerebral Artery Hematology medicine.disease Magnetic Resonance Imaging Work-up Family planning Methylenetetrahydrofolate reductase Mutation Etiology biology.protein Female business |
| Zdroj: | Hamostaseologie. 29 |
| ISSN: | 0720-9355 |
| Popis: | SummarySevere stroke in children and adolescents with its devastating long term consequences remains a rare disorder with many open questions. Beside the well known risk factors such as infection or congenital and acquired heart disease, coagulation disorders have to be considered in the differential work up of the underlying aetiology. Here we report the case of an adolescent with a homozygote MTHFR 677CT mutation suffering a malignant stroke shortly after the start of oral contraceptives. Conclusion: Since prevention seems easily feasible, general screening for MTHFR mutations might be worthwhile in women before starting oral contraceptives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|