Spontaneous regression of quiescent gestational trophoblastic disease after pregnancy: a case report

Autor: Shingo Miyamoto, Koji Matsumoto, Tetsuya Ishikawa, Yoshiyuki Okada, Takashi Mimura, Akihiko Sekizawa
Rok vydání: 2019
Předmět:
Adult
endocrine system
medicine.medical_specialty
medicine.medical_treatment
Remission
Spontaneous
Uterus
Reproductive medicine
Case Report
lcsh:Gynecology and obstetrics
Chorionic Gonadotropin
Human chorionic gonadotropin
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
030212 general & internal medicine
lcsh:RG1-991
reproductive and urinary physiology
Spontaneous regression
Chemotherapy
030219 obstetrics & reproductive medicine
Obstetrics
Gestational trophoblastic disease
business.industry
lcsh:Public aspects of medicine
Quiescent gestational trophoblastic disease
Therapeutic effect
Obstetrics and Gynecology
lcsh:RA1-1270
Hydatidiform Mole
General Medicine
Successful pregnancy
medicine.disease
medicine.anatomical_structure
Reproductive Medicine
Uterine Neoplasms
Female
business
hormones
hormone substitutes
and hormone antagonists
Zdroj: BMC Women's Health
BMC Women's Health, Vol 19, Iss 1, Pp 1-3 (2019)
ISSN: 1472-6874
Popis: Background A persistent low-level elevation of serum human chorionic gonadotropin (hCG) without clinical or radiological evidence of pregnancy or tumors was recently defined as quiescent gestational trophoblastic disease (Q-GTD). Whether patients with Q-GTD should be treated or allowed to become pregnant remains unclear. We herein report a rare case of Q-GTD in which the hCG level spontaneously returned to normal after a successful pregnancy. Case presentation The patient was a 37-year-old primigravida who presented with a persistent low-level elevation of hCG after uterine evacuation of a hydatidiform mole. There was no evidence of neoplasia in the uterus or distant metastasis. The low-level elevation of hCG persisted for at least 2 years but never exceeded 200 mIU/mL. The patient had a successful pregnancy at the age of 40 years. Conclusions Interestingly, her hCG level subsequently normalized without chemotherapy. The present case may imply the safety and therapeutic effect of pregnancy in women with Q-GTD.
Databáze: OpenAIRE
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