Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum
| Autor: | A, Chadie, S, Radi, L, Trestard, A, Charollais, D, Eurin, E, Verspyck, S, Marret, V, Brossard |
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| Rok vydání: | 2008 |
| Předmět: |
Pediatrics
medicine.medical_specialty Developmental Disabilities Intelligence Prenatal diagnosis Ultrasonography Prenatal Central nervous system disease Neuroimaging Humans Medicine Child Agenesis of the corpus callosum Psychomotor learning Pregnancy medicine.diagnostic_test Corpus Callosum Agenesis business.industry Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Child Preschool Pediatrics Perinatology and Child Health Agenesis of Corpus Callosum Nervous System Diseases business Follow-Up Studies |
| Zdroj: | Acta Paediatrica. 97:420-424 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.2008.00688.x |
| Popis: | Aim: To evaluate long-term neurodevelopmental outcomes in children with prenatally diagnosed, isolated agenesis of the corpus callosum (ACC). Methods: We retrospectively reviewed data for 20 children born between January 1991 and November 2003 in the Haute-Normandie region of France with a prenatal diagnosis of isolated ACC. We collected data on pre-and postnatal neuroimaging findings, clinical features at birth and neurodevelopmental outcomes. Results: Follow-up ranged from 3 to 16 years. ACC was complete in 11 patients (55%), partial in 2 (10%), hypoplastic in 3 (15%) and associated with an interhemispheric cyst in 4 (20%). Neurodevelopmental outcome was normal in 11 (55%) patients, including 8 with complete ACC; moderate disability was present in 5 (25%) patients and severe disability in 4 (20%) patients. In 3 of the 4 patients with severe disability, postnatal cerebral magnetic resonance imaging (MRI) showed additional major cerebral abnormalities. Conclusion: Neurodevelopmental outcome was good in most of our patients with isolated ACC, with 80% of patients having normal outcomes or moderate disabilities. A prenatal diagnosis of isolated ACC may not warrant termination of pregnancy. A carefully interpreted prenatal cerebral MRI is crucial to detect associated cerebral abnormalities; a longer follow-up is necessary to look for moderate disabilities. |
| Databáze: | OpenAIRE |
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