Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women
| Autor: | Anne M. Koivisto, Sanna-Kaisa Herukka, Merja Kokki, Päivi Hartikainen, Hannu Kokki, Tuomo Hänninen, Eino Solje, Fanni Haapalinna, Teemu Paajanen, Janne Penttinen, Anne M. Remes |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Amyloid beta Cognitive Neuroscience Disease Delayed recall lcsh:Geriatrics Memory performance lcsh:RC346-429 Alzheimer’s disease 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Cognition CERAD Internal medicine mental disorders medicine Original Research Article ta515 lcsh:Neurology. Diseases of the nervous system Screening dementia Recall biology Mild cognitive impairment Alzheimer's disease ta3124 3. Good health Psychiatry and Mental health lcsh:RC952-954.6 030104 developmental biology Endocrinology biology.protein Delayed Memory Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Dementia and Geriatric Cognitive Disorders Extra, Vol 6, Iss 2, Pp 303-312 (2016) Dementia and Geriatric Cognitive Disorders EXTRA |
| ISSN: | 1664-5464 |
| Popis: | Background: Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive tool; however, only few studies have examined its relationship with CSF biomarkers for AD. We studied the correlation of pathological changes in CSF biomarkers with various CERAD-NB subtests and total scores. Methods: Out of 79 subjects (36 men, mean age 70.5 years), 63 had undergone an assessment of cognitive status with CERAD-NB and a CSF biomarker analysis due to a suspected memory disorder, and 16 were controls with no memory complaint.Results: In women we found a significant correlation between CSF amyloid-beta (Aβ1-42) and several subtests measuring delayed recall. Word List Recall correlated with all markers: Aβ1-42 (r = 0.323, p = 0.035), tau (r = -0.304, p = 0.050) and hyperphosphorylated tau (r = -0.331, p = 0.046). No such correlations were found in men. Conclusions: CSF biomarkers correlate with delayed memory scores in CERAD-NB in women, and women may have more actual AD pathology at the time of the investigations than men. |
| Databáze: | OpenAIRE |
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