Dose-Escalated Radiation Therapy for Pancreatic Cancer: A Simultaneous Integrated Boost Approach
| Autor: | Joseph M. Herman, Eugene J. Koay, Neal Rebueno, William A. Hall, Christopher H. Crane, Beth Erickson, Alexander N. Hanania, Cullen M. Taniguchi, K. Aitken, Sten Myrehaug, Laura A. Dawson |
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| Rok vydání: | 2019 |
| Předmět: |
Simultaneous integrated boost
Organs at Risk medicine.medical_specialty medicine.medical_treatment Planning target volume Dose constraints Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Pancreatic cancer medicine Dose escalation Humans Radiology Nuclear Medicine and imaging Medical physics Particle therapy business.industry Radiotherapy Planning Computer-Assisted Radiotherapy Dosage Intensity-modulated radiation therapy medicine.disease Radiation therapy Pancreatic Neoplasms Oncology 030220 oncology & carcinogenesis Radiotherapy Intensity-Modulated business |
| Zdroj: | Pract Radiat Oncol |
| ISSN: | 1879-8519 |
| Popis: | Purpose To provide a detailed description of practical approaches to dose escalation in pancreatic cancer. Methods and Materials The current paper represents an international collaborative effort of radiation oncologists from the MR-linac consortium with expertise in pancreatic dose escalation. Results A 15-fraction hypofractionated intensity modulated radiation therapy (67.5 Gy in 15 fractions) and 5-fraction stereotactic body radiation therapy case (50 Gy in 5 fractions) are presented with information regarding patient selection, target volumes, organs at risk, dose constraints, and specific considerations regarding quality assurance. Additionally, we address barriers to dose escalation and briefly discuss future directions in dose escalation for pancreatic cancer, including particle therapy and magnetic resonance guided radiation therapy. Conclusions This article on dose escalation for pancreatic cancer may help to guide academic and community based physicians and to serve as a reference for future therapeutic trials. |
| Databáze: | OpenAIRE |
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