Diagnostic Value of High-Sensitivity Troponin T for Subclinical Left Ventricular Systolic Dysfunction in Patients with Sepsis
| Autor: | Le Thi Viet Hoa, Pham Dang Hai, Pham Nguyen Son, Nguyen Thanh Binh, Nguyen Hong Tot, Ha Manh Hung, Nguyen Viet Quang Hien |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Article Subject 030204 cardiovascular system & hematology law.invention Sepsis 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine Diseases of the circulatory (Cardiovascular) system Prospective cohort study Subclinical infection Receiver operating characteristic business.industry Septic shock 030208 emergency & critical care medicine medicine.disease Intensive care unit RC666-701 Cardiology Biomarker (medicine) Cardiology and Cardiovascular Medicine business Research Article |
| Zdroj: | Cardiology Research and Practice Cardiology Research and Practice, Vol 2021 (2021) |
| ISSN: | 2090-0597 2090-8016 |
| Popis: | Background. Left ventricular systolic dysfunction (LVSD) is common in sepsis. Speckle-tracking echocardiography (STE) is a useful emerging tool for evaluating the intrinsic left ventricular systolic function. High-sensitivity cardiac troponin T (hs-cTnT) is the most sensitive biomarker of myocardial injury. However, there are limited data regarding the association between hs-cTnT level and left ventricular systolic dysfunction based on STE in septic patients. We performed this prospective study to evaluate the diagnostic value of hs-cTnT level for subclinical left ventricular systolic dysfunction measured by STE in septic patients according to the sepsis-3 definition. Methods. Patients with sepsis based on sepsis-3 definition admitted to the intensive care unit were prospectively performed STE and hs-cTnT level within 24 hours after the onset of sepsis. Baseline clinical and echocardiographic variables were collected. Left ventricular systolic dysfunction was defined as a global longitudinal strain of ≥−15%. Results. During a 19-month period, 116 patients were enrolled in the study. The elevated hs-cTnT level was seen in 86.2% of septic patients, and 43.1% of patients had LVSD on STE. The median hs-cTnT level and the proportion of elevated hs-cTnT level (>14 ng/L) were significantly higher in patients with LVSD than in patients without LVSD. The area under the ROC curves of hs-cTnT to detect LVSD was 0.73 ( P P = 0.025) and septic shock (HR, 7.6; 95% CI, 2.25 to 25.76; P = 0.001) were independent predictors of LVSD. Conclusion. Our study indicated that the serum hs-cTnT level might be a useful biomarker for detecting LVSD in septic patients. |
| Databáze: | OpenAIRE |
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