Therapeutic outcomes of pemphigus in a referral service in Northern Brazil: a retrospective study of 32 patients
| Autor: | Yandra Sherring Einecke, Marília Brasil Xavier, Amanda Gabay Moreira, Carla Andréa Avelar Pires, Caio César Chaves Costa, Alyne Condurú dos Santos Cunha, Nathalia Gabay Pereira, Fernanda do Nascimento Rodrigues |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Treatment outcome Dermatology Referral service 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Vesiculobullous Skin Diseases immune system diseases Medicine Humans skin and connective tissue diseases Referral and Consultation Retrospective Studies 030203 arthritis & rheumatology integumentary system business.industry Retrospective cohort study Middle Aged medicine.disease Pemphigus Treatment Outcome Female business Brazil |
| Zdroj: | The Journal of dermatological treatment. 32(8) |
| ISSN: | 1471-1753 |
| Popis: | Pemphigus are rare chronic autoimmune blistering disorders with challenging therapeutic management.To investigate the therapeutic outcomes of pemphigus patients admitted to a dermatology referral service in northern Brazil.We conducted a retrospective analysis of 32 patients with histopathological diagnosis of pemphigus between 2010 and 2016. Clinical and epidemiological data were collected. Therapeutic outcome was evaluated according to the criteria proposed by the International Pemphigus Committee. Pemphigus Disease Area Index (PDAI) was used to quantify disease severity.Of the 32 patients, 68.75% had pemphigus vulgaris (PV) and 31.25% had pemphigus foliaceus (PF). Female-to-male ratio was 1:1. The average age was 49.5 years. All patients received oral prednisone as the first-line therapy. Adjuvant immunosuppressive drugs were gradually added in refractory and/or severe cases. After 24 months of treatment, disease control and complete remission rates were 37.5% and 25%, respectively. The mortality rate was 9.37%. PDAI score was significantly lower at 24 months of therapeutic follow-up (Therapeutic management with corticosteroids and/or immunosuppressive drugs was able to induce disease control/complete remission in most of patients. PDAI was a useful tool for objective assessment of disease severity during therapeutic follow-up. |
| Databáze: | OpenAIRE |
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