IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever
| Autor: | Julio Reyes-Leyva, Virginia Sedeño-Monge, Tania Estrada-Jiménez, Margarita Moreno, Lilian Flores-Mendoza, Lourdes Millán-Pérez Peña, María del Consuelo Manjarrez, Guadalupe González-Ochoa |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Article Subject medicine.medical_treatment 030231 tropical medicine Immunology Biology Dengue fever Interferon-gamma 03 medical and health sciences Suppressor of Cytokine Signaling 1 Protein 0302 clinical medicine Immune system Interferon lcsh:Pathology medicine Animals Humans Severe Dengue SOCS3 Interleukin-6 Tumor Necrosis Factor-alpha Suppressor of cytokine signaling 1 Cell Biology Flow Cytometry medicine.disease Interleukin-10 Interleukin 10 030104 developmental biology Cytokine Suppressor of Cytokine Signaling 3 Protein Interleukin-2 Female Tumor necrosis factor alpha Interleukin-4 Biomarkers Research Article lcsh:RB1-214 medicine.drug |
| Zdroj: | Mediators of Inflammation, Vol 2017 (2017) Mediators of Inflammation |
| ISSN: | 0962-9351 |
| DOI: | 10.1155/2017/5197592 |
| Popis: | Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs) that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue.Objective. To explore the association of cytokine andsocslevels with disease severity in dengue patients.Methods. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN-)γ, and tumor necrosis factor- (TNF-)αwere quantified by flow cytometry, and the relative expression ofsocs1andsocs3mRNA was quantified by real-time RT-PCR.Results. Increased levels of IL-10 and socs3 and lower expression ofsocs1were found in patients with dengue hemorrhagic fever (DHF) with respect to those with dengue fever (DF) (p<0.05). Negative correlations were found betweensocs1and both IL-10 andsocs3(p<0.01). The cutoff values ofsocs3(>199.8-fold),socs1(134 pg/ml) have the highest sensitivity and specificity to discriminate between DF and DHF.Conclusion. Simultaneous changes in IL-10 andsocs1/socs3could be used as prognostic biomarkers of dengue severity. |
| Databáze: | OpenAIRE |
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