Radioguided surgery with β − radiation in pancreatic Neuroendocrine Tumors: a feasibility study

Autor:	Riccardo Faccini, Giuseppe Quero, Teresa Scotognella, Francesco Collamati, M. Fischetti, Micol De Simoni, Ilaria Fratoddi, Alessandro Giordano, Sergio Alfieri, Silvio Morganti, V. Bocci, R. Mirabelli, Elena Solfaroli Camillocci, Iole Venditti, Angela Collarino, Giacomo Traini, Antonella Cartoni, Daria Maccora, Carlo Mancini-Terracciano, Dante Rotili
Přispěvatelé:	Collamati, F., Maccora, D., Alfieri, S., Bocci, V., Cartoni, A., Collarino, A., Simoni, M. D., Fischetti, M., Fratoddi, I., Giordano, A., Mancini-Terracciano, C., Mirabelli, R., Morganti, S., Quero, G., Rotili, D., Scotognella, T., Solfaroli Camillocci, E., Traini, G., Venditti, I., Faccini, R.
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male lcsh:Medicine Neuroendocrine tumors Octreotide Article 030218 nuclear medicine & medical imaging Meningioma 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Positron Emission Tomography Computed Tomography Intestinal Neoplasms medicine Humans lcsh:Science Positron Emission Tomography-Computed Tomography Aged Multidisciplinary business.industry Intestinal Neuroendocrine Tumor lcsh:R Applied physics Oncology Preclinical research Translational research Radioguided Surgery Middle Aged medicine.disease Beta Particles Pancreatic Neoplasms Neuroendocrine Tumors medicine.anatomical_structure Surgery Computer-Assisted 030220 oncology & carcinogenesis Female lcsh:Q Sampling time Pancreas Nuclear medicine business β radiation Algorithms
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-61075-2
Popis:	The possibility to use β− decaying isotopes for radioguided surgery (RGS) has been recently proposed, and first promising tests on ex-vivo samples of Meningioma and intestinal Neuroendocrine Tumor (NET) have been published. This paper reports a study of the uptake of 68Ga-DOTATOC in pancreatic NETs (pNETs) in order to assess the feasibility of a new RGS approach using 90Y-DOTATOC. Tumor and healthy pancreas uptakes were estimated from 68Ga-DOTATOC PET/CT scans of 30 patients with pNETs. From the obtained SUVs (Standardised Uptake Value) and TNRs (Tumor Non tumor Ratio), an analysis algorithm relying on a Monte Carlo simulation of the detector has been applied to evaluate the performances of the proposed technique. Almost all considered patients resulted to be compatible with the application of β−-RGS assuming to administer 1.5 MBq/kg of activity of 90Y-DOTATOC 24 h before surgery, and a sampling time of few seconds. In just 2 cases the technique would have required a mildly increased amount of activity or of sampling time. Despite a high physiological uptake of 68Ga-DOTATOC in the healthy pancreas, the proposed RGS technique promises to be effective. This approach allows RGS to find application also in pancreatic diseases, where traditional techniques are not viable.
Databáze:	OpenAIRE
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