The impact of aerobic exercise training on novel adipokines, apelin and ghrelin, in patients with type 2 diabetes
| Autor: | Nikoletta Angelopoulou, Alkistis Kapelouzou, Nikolaos P.E. Kadoglou, Christos D. Liapis, Alkiviadis Kostakis, Stilianos Lampropoulos, Ioannis S. Vrabas, Nikolaos Sailer |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Adipokine Type 2 diabetes Clinical Research Internal medicine Diabetes mellitus medicine Humans Aerobic exercise adipokines Glycemic exercise business.industry Insulin General Medicine Middle Aged medicine.disease Ghrelin Apelin Endocrinology apelin Diabetes Mellitus Type 2 Intercellular Signaling Peptides and Proteins Female type 2 diabetes business |
| Zdroj: | Scopus-Elsevier Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1234-1010 |
| Popis: | Summary Background Accumulating data support the atheroprotective role of the novel adipokines, apelin and ghrelin. The aim of the present randomized study was to investigate the effects of aerobic exercise training on these adipokines in patients with type 2 diabetes mellitus (T2DM). Material/Methods Fifty-four overweight (BMI >25 kg/m2) patients with T2DM, but without vascular complications, were randomized to either the aerobic exercise training group (EG, N=27), 4 times/week, 45–60 min/session; or to the control group (CG, N=27), orally instructed to increase physical activity. Clinical glycemic and lipid parameters, exercise capacity (VO2peak), insulin, HOMA-IR, and serum levels of apelin and ghrelin were assessed at baseline and after 12 weeks. Results Aerobic exercise significantly improved lipid and glycemic profile and insulin sensitivity compared to CG (p0.05). However, subgroup analysis revealed a considerable increment in ghrelin levels only in the exercise-treated women compared to their control counterparts (p=0.038). LDL and HOMA-IR reduction were found to be independent predictors of apelin increment in multiple regression analysis (R2=0.391, p=0.011). Conclusions In patients with T2DM, systemic, long-term, aerobic exercise exerts positive effects on apelin and ghrelin (only in women), even in the absence of significant weight loss, suggesting its pleiotropic effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|