Spontaneous and Dosing Route-related Lung Lesions in Beagle Dogs from Oral Gavage and Inhalation Toxicity Studies: Differentiation from Compound-induced Lesions
| Autor: | Sydney Mukaratirwa, Kaori Isobe, Begonya Garcia, Alys Bradley, Claudio Petterino |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty 040301 veterinary sciences Administration Oral Aspiration pneumonia Toxicology Beagle Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences Route of administration Dogs Administration Inhalation Toxicity Tests medicine Animals Molecular Biology Lung Inhalation business.industry 04 agricultural and veterinary sciences Cell Biology medicine.disease Mononuclear cell infiltration 030104 developmental biology medicine.anatomical_structure Toxicity business Infiltration (medical) |
| Zdroj: | Toxicologic pathology. 44(7) |
| ISSN: | 1533-1601 |
| Popis: | This study was conducted to characterize lung microscopic lesions in control beagle dogs from inhalation and oral gavage toxicity studies, to determine differences associated with the route of administration, and to discuss distinguishing features from compound-induced lung lesions. Samples from 138 control dogs from oral gavage studies and 124 control dogs from inhalation (vehicle control) studies were evaluated microscopically. There was no significant sex-related difference in the incidence of all lesions. Perivascular mononuclear cell infiltration, centriacinar mixed cell infiltration, bronchopneumonia, subpleural septal fibrosis, and alveolar macrophage accumulation were the most common lesions. Aspiration pneumonia was more common in dogs from gavage studies, suggesting reflux after gavage dosing or accidental administration of test formulation as possible causes. Centriacinar mixed cell infiltration was more common in dogs from inhalation studies, suggesting mild irritation by the vehicles used. Vascular lesions, which included pulmonary arteriopathy and smooth muscle mineralization, were observed in a few animals. Some of the spontaneous lesions are similar to lesions induced by test compounds. Compared to spontaneous lesions, compound-induced lesions tend to be multifocal or diffuse, follow a pattern of distribution (e.g., centriacinar, perivascular, and interstitial), show a dose response in the incidence and severity, and may show cell-specific toxicity. |
| Databáze: | OpenAIRE |
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