The human HTLV-3 and HTLV-4 retroviruses: new members of the HTLV family
| Autor: | Renaud Mahieux, Antoine Gessain |
|---|---|
| Přispěvatelé: | Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
viruses
Population Simian MESH: Africa medicine.disease_cause MESH: Deltaretrovirus Deltaretrovirus Virus 03 medical and health sciences Retrovirus immune system diseases hemic and lymphatic diseases medicine Animals Humans MESH: Animals education 030304 developmental biology Genetics Human T-lymphotropic virus 1 0303 health sciences education.field_of_study Deltaretrovirus Infections MESH: Human T-lymphotropic virus 1 MESH: Humans biology MESH: Human T-lymphotropic virus 2 030306 microbiology Human T-lymphotropic virus 2 Primate Diseases virus diseases General Medicine Simian immunodeficiency virus biology.organism_classification Virology 3. Good health MESH: Primate Diseases Africa Lentivirus Viral disease MESH: Deltaretrovirus Infections |
| Zdroj: | Pathologie Biologie Pathologie Biologie, Elsevier Masson, 2009, 57 (2), pp.161-6. ⟨10.1016/j.patbio.2008.02.015⟩ Pathologie Biologie, 2009, 57 (2), pp.161-6. ⟨10.1016/j.patbio.2008.02.015⟩ |
| ISSN: | 0369-8114 |
| DOI: | 10.1016/j.patbio.2008.02.015⟩ |
| Popis: | International audience; Human T cell leukemia/lymphoma virus Type 1 and 2 (HTLV-1 and HTLV-2), together with their simian counterparts (STLV-1, STLV-2), belong to the Primate T lymphotropic viruses group (PTLV). HTLV-1 infects 15 to 20million people worldwide, while STLV-1 is endemic in a number of simian or ape species living in Africa or Asia. The high percentage of homologies between HTLV-1 and STLV-1 strains, led to the demonstration that most HTLV-1 subtypes arose from interspecies transmission between monkeys and humans. STLV-3 viruses belong to the third PTLV type and are equally divergent from HTLV-1 than from HTLV-2. They are endemic in several monkey species that live in West, Central, and East Africa. In 2005, we and others reported the discovery of the human homolog (HTLV-3) of STLV-3 in two asymptomatic inhabitants from South Cameroon whose sera exhibited HTLV indeterminate serologies. More recently, we reported a third case of HTLV-3 infection in Cameroon suggesting that this virus is not rare in the human population living in Central Africa. Together with STLV-3, these three human viral strains belong therefore to the PTLV-3 type. A fourth HTLV type (HTLV-4) was also discovered in the same geographical area. Current studies are aimed at determining the prevalence, distribution and modes of transmission of these viruses as well as their possible association with human diseases. Furthermore, molecular characterization of their viral transactivator Tax is ongoing in order to look for possible oncogenic properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect