Systemic sclerosis and antineutrophil cytoplasmic autoantibody-associated renal failure
| Autor: | A. Katrib, A. Sturgess, J. V. Bertouch |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Systemic disease Time Factors Immunology Scleroderma Renal Crisis urologic and male genital diseases Scleroderma Antibodies Antineutrophil Cytoplasmic Rheumatology Immunology and Allergy Medicine Humans Renal Insufficiency skin and connective tissue diseases Anti-neutrophil cytoplasmic antibody Aged Scleroderma Systemic integumentary system business.industry Microangiopathy Autoantibody Middle Aged medicine.disease Connective tissue disease Female business Kidney disease |
| Zdroj: | Rheumatology international. 19(1-2) |
| ISSN: | 0172-8172 |
| Popis: | We report three patients who developed antineutrophil cytoplasmic autoantibody (ANCA)-associated crescentic glomerulonephritis, two of whom showed clinical features of limited scleroderma and one whose results of serological tests were suggestive of limited scleroderma without cutaneous features. All had anticentromere antibodies and antimyeloperoxidase antibodies. No patient showed the features of typical scleroderma renal crisis such as accelerated hypertension or microangiopathy. Our patients were normotensive at the time of onset of renal failure, and the clinical picture was characterised by only modest features of limited scleroderma. All three patients had crescentic glomerulonephritis at various stages of chronicity. One patient responded to immunosuppressive therapy with improvement in renal function; the other two patients rapidly developed end-stage renal failure. These patients and others recently described may represent a newly described form of scleroderma renal disease. |
| Databáze: | OpenAIRE |
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