Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma

Autor: U. A. Boyarskih, Elena N. Voronina, Alexandra S. Weiner, T. I. Pospelova, E. N. Voropaeva, Olga V. Beresina, Maxim L. Filipenko
Rok vydání: 2010
Předmět:
Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Adolescent
Genotype
MTHFD1
Cystathionine beta-Synthase
Single-nucleotide polymorphism
Biology
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Polymorphism
Single Nucleotide
Linkage Disequilibrium
Minor Histocompatibility Antigens
Young Adult
Folic Acid
Gene Frequency
Meta-Analysis as Topic
Risk Factors
hemic and lymphatic diseases
Internal medicine
medicine
Odds Ratio
Humans
Allele
Alleles
Methylenetetrahydrofolate Reductase (NADPH2)
Aged
Genetics
Glycine Hydroxymethyltransferase
Methylenetetrahydrofolate Dehydrogenase (NADP)
Lymphoma
Non-Hodgkin
Hematology
Middle Aged
medicine.disease
MTRR
Genotype frequency
Non-Hodgkin's lymphoma
Ferredoxin-NADP Reductase
Methylenetetrahydrofolate reductase
biology.protein
Female
Metabolic Networks and Pathways
Zdroj: Leukemia research. 35(4)
ISSN: 1873-5835
Popis: We investigated the role of single nucleotide polymorphisms (SNPs) in the folate-metabolizing genes MTHFR, MTR, MTRR, MTHFD, CBS and SHMT in regulating genetic susceptibility to Non-Hodgkin's lymphoma (NHL). We determined the allele and genotype frequencies in the case group (146 patients with NHL) and the control group (540 blood donors). A significant association with NHL was observed only for MTHFD1 G1958A (allele G OR = 1.382, P = 0.05; genotype GA OR = 2.316, P = 0.01; genotype GG OR = 2.153, P = 0.03). After additional stratification of case and control groups according to sex and tumor type association of MTHFD1 G1958A with NHL was observed only in high-grade NHL subgroup (allele G OR = 1.664, P = 0.01) and in women subgroup (allele G OR = 2.043, P = 0.009). Meta-analysis for SNPs in the MTHFR, MTR, MTRR and SHMT revealed a reducing effect of the MTR 2756G allele on the risk of NHL (OR = 0.902; 95% CI 0.821–0.991, P = 0.03).
Databáze: OpenAIRE
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