A Single-Dose Study of Mexiletine (Kö 1173)
| Autor: | L. D. Smith, J. K. Penry, R. E. Ramsey, R. J. Perchalski, W. D. Yonekawa, James J. Cereghino, H. J. Kupferberg, B. J. Wilder, B. G. White |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Drug Complex partial seizures medicine.medical_treatment media_common.quotation_subject Mexiletine Pharmacology Epilepsy medicine Humans media_common Dose-Response Relationship Drug Propylamines business.industry Middle Aged Serum concentration medicine.disease Anticonvulsant Neurology Anticonvulsants Neurology (clinical) business medicine.drug |
| Zdroj: | Epilepsia. 16:665-672 |
| ISSN: | 1528-1167 0013-9580 |
| Popis: | Serum concentrations of mexiletine after a single dose were determined in 8 adult Caucasian males with complex partial seizures who were continuing to receive other antiepileptic drugs. Two patients each received a single dose of either 100, 200, 300, or 400 mg mexiletine. Serum concentrations were determined by two gas chromatographic methods. Serum concentrations ranged up to 795 ng/ml. Peak concentrations occurred 1 to 3 hr after administration of the drug and were significantly different between the 100- and 300-mg, 100- and 400-mg, 200- and 300-mg, and 200- and 400-mg doses. Differences between the other doses were not significant. Serum concentrations declined monoexponentially. Half-life ranged from 2.7 to 7.2 hr. Numerous papers have appeared in the European literature on the use of mexiletine to treat cardiac arrhythmias. Preliminary studies in the United States suggest the use of mexiletine as an adjunct for therapy of epilepsy. |
| Databáze: | OpenAIRE |
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