18F-FDG, 11C-Methionine, and 68Ga-Pentixafor PET/CT in patients with smoldering multiple myeloma: imaging pattern and clinical features
| Autor: | Xiang Zhou, Janin Messerschmidt, Malte Kircher, K. Martin Kortüm, Andreas Schirbel, Alexander Dierks, Mohammad Barakat, David Böckle, Lukas Scheller, Sebastian Knorz, Olivia Kertels, Constantin Lapa, Andreas K. Buck, Hermann Einsele, Leo Rasche, Samuel Samnick |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research smoldering myeloma Lumbar vertebrae Plasma cell lcsh:RC254-282 Article 03 medical and health sciences 0302 clinical medicine medicine 68Ga-pentixafor In patient 68Ga-Pentixafor PET/CT ddc:610 Multiple myeloma PET-CT medicine.diagnostic_test business.industry 18F-FDG PET/CT medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology medicine.anatomical_structure Oncology Positron emission tomography 030220 oncology & carcinogenesis 11C-Methionine PET/CT Bone marrow Nuclear medicine business |
| Zdroj: | Cancers Volume 12 Issue 8 Cancers, Vol 12, Iss 2333, p 2333 (2020) |
| Popis: | This study aimed to explore the correlation between imaging patterns and clinical features in patients with smoldering multiple myeloma (SMM) who simultaneously underwent 18F-FDG, 11C-Methionine, and 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT). We retrieved and analyzed clinical characteristics and PET imaging data of 10 patients with SMM. We found a significant correlation between bone marrow (BM) plasma cell (PC) infiltration and mean standardized uptake values (SUVmean) of lumbar vertebrae L2-L4 on 11C-Methionine PET/CT scans (r = 0.676, p = 0.031) and 68Ga-Pentixafor PET/CT scans (r = 0.839, p = 0.002). However, there was no significant correlation between BM involvement and SUVmean of lumbar vertebrae L2-L4 on 18F-FDG PET/CT scans (r = 0.558, p = 0.093). Similarly, mean target-to-background ratios (TBRmean) of lumbar vertebrae L2-L4 also correlated with bone marrow plasma cell (BMPC) infiltration in 11C-Methionine PET/CT (r = 0.789, p = 0.007) and 68Ga-Pentixafor PET/CT (r = 0.724, p = 0.018) PET/CT. In contrast, we did not observe a significant correlation between BMPC infiltration rate and TBRmean in 18F-FDG PET/CT (r = 0.355, p = 0.313). Additionally, on 11C-Methionine PET/CT scans, we found a significant correlation between BMPC infiltration and TBRmax of lumbar vertebrae L2-L4 (r = 0.642, p = 0.045). In conclusion, 11C-Methionine and 68Ga-Pentixafor PET/CT demonstrate higher sensitivity than 18F-FDG PET/CT in detecting BM involvement in SMM. |
| Databáze: | OpenAIRE |
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