Neo¬clerodane diterpenoids from Reehal Fatima, Teucrium yemense
| Autor: | David M. Fazakerley, Ifat Parveen, Ebtesam S. Al-Sheddi, Mohammad Nur-e-Alam, Muhammad Yousaf, Adnan J. Al-Rehaily, Hazem A. Ghabbour, Kezia C. L. Whatley, Michael D. Threadgill, Sarfaraz Ahmed, Ahmed Bari, Karl F. Hoffmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus Mycobacterium smegmatis Molecular Conformation Saudi Arabia Pharmaceutical Science Microbial Sensitivity Tests Crystallography X-Ray 01 natural sciences Diterpenes Clerodane Teucrium Analytical Chemistry 03 medical and health sciences Genus Candida albicans Drug Discovery Botany Escherichia coli Humans Nuclear Magnetic Resonance Biomolecular Pharmacology Lamiaceae Plants Medicinal Molecular Structure biology 010405 organic chemistry Organic Chemistry Hep G2 Cells biology.organism_classification 0104 chemical sciences 030104 developmental biology Complementary and alternative medicine Phytochemical Pseudomonas aeruginosa Molecular Medicine Diterpenes |
| Zdroj: | Nur-e-Alam, M, Yousaf, M, Ahmed, S, Al-Sheddi, E S, Parveen, I, Fazakerley, D M, Bari, A, Ghabbour, H A, Threadgill, M, Whatley, K C L, Hoffmann, K F & Al-Rehaily, A N 2017, ' Neo¬clerodane diterpenoids from Reehal Fatima, Teucrium yemense ', Journal of Natural Products, vol. 80, no. 6, pp. 1900-1908 . https://doi.org/10.1021/acs.jnatprod.7b00188 |
| DOI: | 10.1021/acs.jnatprod.7b00188 |
| Popis: | Teucrium yemense (Defl) (T. yemense), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A-E (1, 2, 3, 5, 6) and fatimanone (4), and the known teulepicephin (7). As both the Teucrium genus and the related Lamiaceae family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterisation of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles, and by comparison to related compounds. The structure of fatimanol D (5) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus. |
| Databáze: | OpenAIRE |
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