Association of mannose-binding lectin levels and invasive fungal disease in hematologic malignancy patients receiving myelosuppressive chemotherapy or allogeneic hematopoietic stem cell transplantation
| Autor: | Christina Cline, Clay A. Bennett, Michele W. Sugrue, J Stokes, John W. Hiemenz, Jack W. Hsu, Mary Riwes, Helen Leather, Dan Neal, John R. Wingard |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty medicine.medical_treatment chemical and pharmacologic phenomena Hematopoietic stem cell transplantation Mannose-Binding Lectin Gastroenterology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Progenitor cell Aged Mannan-binding lectin Transplantation Myelosuppressive Chemotherapy business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged bacterial infections and mycoses medicine.disease MBL deficiency 030104 developmental biology Graft-versus-host disease Mycoses Hematologic Neoplasms Immunology Female Stem cell business Immunosuppressive Agents 030215 immunology |
| Zdroj: | Bone Marrow Transplantation. 51:1228-1232 |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | Several studies have suggested an association of mannose-binding lectin (MBL) deficiency with infections. In this study, we investigated the association between MBL deficiency and invasive fungal disease (IFD) in hematologic malignancy patients receiving myelosuppressive chemotherapy or hematopoietic stem cell transplant. MBL levels were quantified at the start of treatment in 152 patients who were followed for 6 months and scored as developing IFD or not. Forty-five patients (29.6%) developed IFD, of which 21 (46.7% of IFD cases and 13.8% of patients) were proven or probable IFD. Fifty-nine (38.8%) had MBL levels |
| Databáze: | OpenAIRE |
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