Effects of brain radiotherapy on cognitive performance in adult low-grade glioma patients: A systematic review
| Autor: | Nektarios Mazarakis, Paul Chumas, Spyridon Komaitis, Georgios Stranjalis, Daniel J. O’Hara, Eleftherios Neromyliotis, Christos Koutsarnakis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult medicine.medical_specialty medicine.medical_treatment 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cognition Quality of life Internal medicine Grade II Glioma Medicine Humans Radiology Nuclear Medicine and imaging Progression-free survival Prospective Studies Cognitive decline Cognitive deficit business.industry Brain Neoplasms Neuropsychology Brain Hematology Glioma Radiation therapy 030220 oncology & carcinogenesis Quality of Life medicine.symptom business |
| Zdroj: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 160 |
| ISSN: | 1879-0887 |
| Popis: | Grade II gliomas are slow growing tumours that usually affect younger patients. The mainstream treatment modality at present is surgical. The role of radiation therapy in the management of grade II gliomas has been the subject of considerable debate. Radiation therapy has a proven potential to prolong progression free and overall survival in high-risk patients, but may also produce long-term cognitive deficits. Since grade II glioma patients are expected to live several years, retention of cognitive capacity and quality of life is an equally important endpoint as prolonging progression free survival. Our overarching goal is to critically review the available evidence on the possible neuropsychological effects of postoperative radiotherapy in adult grade II glioma patients. We performed a systematic literature search in Medline, Embase and Cochrane databases up to 1st of May 2020 for studies assessing the cognitive effects of radiation therapy on grade II glioma patients. Eleven studies meeting our inclusion criteria provide either negative or contradictory data regarding the cognitive domains affected, while major confounding variables remain incompletely addressed. The available evidence does not adequately support the notion that current radiation therapy protocols independently produce substantial cognitive decline in grade II glioma patients and therefore it would be premature to argue that radiation associated cognitive morbidity outweighs the benefit of prolonged survival. A large prospective study incorporating a full battery of neuropsychological testing, sufficiently long-term follow-up period and tight control of confounders is due to provide high quality data. |
| Databáze: | OpenAIRE |
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