Deterioration of kidney function by high doses of co-trimoxazole in man
| Autor: | Yechiel A. Hekster, M. Martea, J. H. M. Berden, R. Van Klaveren, Jan Willem J. Lammers, Tom B. Vree, E. F. S. Termond |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Sulfamethoxazole media_common.quotation_subject Anti-Infective Agents Urinary Renal function urologic and male genital diseases Trimethoprim Pharmacokinetics Internal medicine Trimethoprim Sulfamethoxazole Drug Combination medicine Crystalluria High doses Humans Pharmacology (medical) media_common Pharmacology business.industry Pneumonia Pneumocystis Drug Combinations Kinetics Endocrinology Kidney Diseases medicine.symptom business Kidney tubules medicine.drug |
| Zdroj: | Pharmaceutisch Weekblad. 9:117-124 |
| ISSN: | 1573-739X 0031-6911 |
| Popis: | High doses of co-trimoxazole in a patient with Pneumocystis carinii and impaired kidney function (creatinine clearance 10 ml/min) resulted in a declining renal clearance of the drug but did not affect the average creatinine clearance. The renal clearance of sulfamethoxazole and its metabolites 5-hydroxy-, N4-acetyl-, N4-acetyl-5-hydroxysulfamethoxazole decreased 80%, while the renal clearance of trimethoprim decreased 60%. The renal clearance of all compounds was evidently dependent on urine flow. The observed phenomena may be explained by the assumption that crystalluria occurred, obstructing kidney tubules. The crystalluria effect can be reversed by cessation of the drug or by lowering its dosage. |
| Databáze: | OpenAIRE |
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