Serum levels of advanced glycation end products are associated with left ventricular diastolic function in patients with type 1 diabetes

Autor: Tore Julsrud Berg, Jesper Mehlsen, Kristian F. Hanssen, Per Hildebrandt, O. Snorgaard, J Faber, Peter A. Torjesen
Rok vydání: 1999
Předmět:
Adult
Glycation End Products
Advanced
Male
Cardiac function curve
medicine.medical_specialty
Systole
Endocrinology
Diabetes and Metabolism
Diastole
Blood Pressure
Doppler echocardiography
Ventricular Function
Left
Coronary artery disease
Ventricular Dysfunction
Left
chemistry.chemical_compound
Diabetic Neuropathies
Heart Rate
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Albuminuria
Humans
Diabetic Nephropathies
Aged
Glycated Hemoglobin
Advanced and Specialized Nursing
Type 1 diabetes
Diabetic Retinopathy
medicine.diagnostic_test
business.industry
Cholesterol
HDL
Cholesterol
LDL
Middle Aged
medicine.disease
Myocardial Contraction
Echocardiography
Doppler
Cholesterol
Diabetes Mellitus
Type 1
Endocrinology
Blood pressure
chemistry
Cardiology
Regression Analysis
Advanced glycation end-product
Female
Collagen
business
Biomarkers
Diabetic Angiopathies
Zdroj: Diabetes Care. 22:1186-1190
ISSN: 1935-5548
0149-5992
Popis: OBJECTIVE: Impairment of left ventricular diastolic function, possibly caused by increased collagen cross-linking of the cardiac muscle, is common in patients with type 1 diabetes even without coronary artery disease. Advanced glycation end products (AGEs) cross-link tissue collagen and are found within myocardial fibers. The aim of this study was to examine for a possible association between circulating AGEs and left ventricular cardiac function. RESEARCH DESIGN AND METHODS: Left ventricular diastolic and systolic function were assessed by M-mode and Doppler echocardiography in 52 patients with type 1 diabetes, age 40 +/- 13 (mean +/- SD) years, diabetes duration 17 +/- 13 years, and HbA1c 8.3 +/- 1.1%. Serum levels of AGEs and N epsilon-(carboxymethyl)lysine (CML) were measured by newly developed competitive immunoassays. RESULTS: A positive correlation was found between serum levels of AGEs and isovolumetric relaxation time (IVRT), r = 0.46 (P < 0.0008), and left ventricular diameter during diastole, r = 0.37 (P < 0.008). The systolic parameters did not correlate with serum levels of AGEs. Stepwise regression analysis showed that 21% of the IVRT variation could be explained by serum levels of AGEs (F = 11.4, P < 0.002), whereas serum levels of CML, HbA1c, albumin excretion rate, diabetes duration, and mean arterial blood pressure were of no importance. AGE levels were significantly increased in men compared with women (P < 0.03) and present or former smokers (P < 0.04). CONCLUSIONS: Increased serum levels of AGEs, unlike serum levels of CML, are associated with heart stiffness in patients with type 1 diabetes, possibly mediated by the cross-linking properties of AGEs.
Databáze: OpenAIRE
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