Dnacins, new antibiotics. I. Producing organism, fermentation, and antimicrobial activities

Autor:	Masayuki Muroi, Toru Hasegawa, Eiji Higashide, Seiichi Tanida
Rok vydání:	1980
Předmět:	Pharmacology Bacteria biology medicine.drug_class fungi Antibiotics Quinones Drug Resistance Microbial biology.organism_classification medicine.disease_cause Antimicrobial Nocardia Anti-Bacterial Agents Spore Microbiology Cell wall Fermentation Drug Discovery medicine Escherichia coli Organism
Zdroj:	The Journal of Antibiotics. 33:1443-1448
ISSN:	1881-1469 0021-8820
Popis:	Dnacins are new antibiotics produced by an actinomycete, strain No. C-14482 (N-1001). The characteristic features of the organism are: the formation of coremia on solid media, production of rod-shaped motile spores with peritrichous flagella from mature aerial mycella, fragmentation of the mature organism (at later stage of growth) in liquid media in which some fragmented elements have motility, lysozyme resistance, meso-diaminopimelic acid in the cell wall, and a guanine-cytosine content of 71 +/- 1 mol%. The organism has been designated as Nocardia sp. No. C-14482 (N-1001). Dnacins show strong activity against various GRam-negative, Gram-positive, and acid-fast bacteria, but slight activity against fungi. The antibiotics hardly affect the growth of Escherichia coli K-12 under anaerobic condition even at concentrations more than five times that of the minimum inhibitory concentrations under aerobic conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1bf3db0dd1bc73cf52ca1aed366d69 https://doi.org/10.7164/antibiotics.33.1443 Zobrazit plný text záznamu