The Ubiquitinated Axon: Local Control of Axon Development and Function by Ubiquitin
| Autor: | Diogo Tomé, Maria J. Pinto, Ramiro D. Almeida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Neurogenesis Cell Growth Cones 03 medical and health sciences 0302 clinical medicine Ubiquitin medicine Animals Humans Axon Control (linguistics) biology General Neuroscience Ubiquitination Axons Viewpoints 030104 developmental biology medicine.anatomical_structure Proteasome Synapses biology.protein Neuroscience 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | J Neurosci |
| Popis: | Ubiquitin tagging sets protein fate. With a wide range of possible patterns and reversibility, ubiquitination can assume many shapes to meet specific demands of a particular cell across time and space. In neurons, unique cells with functionally distinct axons and dendrites harboring dynamic synapses, the ubiquitin code is exploited at the height of its power. Indeed, wide expression of ubiquitination and proteasome machinery at synapses, a diverse brain ubiquitome, and the existence of ubiquitin-related neurodevelopmental diseases support a fundamental role of ubiquitin signaling in the developing and mature brain. While special attention has been given to dendritic ubiquitin-dependent control, how axonal biology is governed by this small but versatile molecule has been considerably less discussed. Herein, we set out to explore the ubiquitin-mediated spatiotemporal control of an axon's lifetime: from its differentiation and growth through presynaptic formation, function, and pruning. |
| Databáze: | OpenAIRE |
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