Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)
| Autor: | Paul F. Hudak, Curtis D. Eckhert, Wade T. Barranco |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
inorganic chemicals Cancer Research Genistein chemistry.chemical_element Environment Boric acid Toxicology chemistry.chemical_compound Prostate cancer Boric Acids Risk Factors Radiation Ionizing Tumor Cells Cultured medicine Anticarcinogenic Agents Humans Selenomethionine Boron Cell Proliferation business.industry Prostatic Neoplasms Water medicine.disease Texas United States Cancer registry Oncology chemistry Toxicity Cancer research Regression Analysis Growth inhibition business Selenium |
| Zdroj: | Cancer Causes & Control. 18:71-77 |
| ISSN: | 1573-7225 0957-5243 |
| DOI: | 10.1007/s10552-006-0077-8 |
| Popis: | To determine: (1) the correlation of prostate cancer incidence and mortality with groundwater boron and selenium concentrations; and (2) the impact of boron on prostate cancer cell proliferation during co-treatment with alternative chemo-preventative agents, along with boron pre-treatment effects on cell sensitivity to ionizing radiation. For regression analysis, data on prostate cancer incidence and mortality were obtained from the Texas Cancer Registry, while groundwater boron and selenium concentrations were derived from the Texas Water Development Board. Cultured DU-145 prostate cancer cells were used to assess the impact of boric acid on cell proliferation when applied in combination with selenomethionine and genistein, or preceding radiation exposure. Groundwater boron levels correlated with a decrease in prostate cancer incidence (R = 0.6) and mortality (R = 0.6) in state planning regions, whereas selenium did not (R = 0.1; R = 0.2). Growth inhibition was greater during combined treatments of boric acid and selenomethionine, or boric acid and genistein, versus singular treatments. 8-day boric acid pre-exposure enhanced the toxicity of ionizing radiation treatment, while dose-dependently decreasing the expression of anti-apoptotic protein Bcl-2. Increased groundwater boron concentrations, across the state of Texas, correlate with reduced risk of prostate cancer incidence and mortality. Also, boric acid improves the anti-proliferative effectiveness of chemo-preventative agents, selenomethionine and genistein, while enhancing ionizing radiation cell kill. |
| Databáze: | OpenAIRE |
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