Transesophageal plane transducer
| Autor: | Dominique Cathignol, Cyril Lafon, Y. Theillere, David Melodelima, Frédéric Prat, Alexei Arefiev |
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| Přispěvatelé: | Applications des ultrasons à la thérapie, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was partially supported by a grant from the French Ministry of National Education, Research, and Technology (MENRT), grant N° 2000/102 (ACI telemedecine and technologies) and by a grant of the Agency for Research on Cancer (ARC), grant N° 4443. |
| Rok vydání: | 2003 |
| Předmět: |
Male
Acoustics and Ultrasonics Esophageal Neoplasms Swine Ultrasonic Therapy MESH: Research Support Non-U.S. Gov't 030218 nuclear medicine & medical imaging 0302 clinical medicine high intensity ultrasound Medicine MESH: Animals sector-based MESH: Swine Radiological and Ultrasound Technology Ultrasound Palliative Care Equipment Design MESH: Ultrasonic Therapy 3. Good health medicine.anatomical_structure Transducer Coagulative necrosis plane transducer 030220 oncology & carcinogenesis MESH: Esophageal Neoplasms Catheter Ablation MESH: Palliative Care [SDV.IB]Life Sciences [q-bio]/Bioengineering Radiology MESH: Transducers medicine.medical_specialty Perforation (oil well) Transducers Biophysics MESH: Echocardiography Transesophageal coagulation necrosis MESH: Echocardiography Transesop Article 03 medical and health sciences thermal ablation In vivo Animals Radiology Nuclear Medicine and imaging Esophagus MESH: Catheter Ablation business.industry Cancer intraductal therapy medicine.disease MESH: Male Surgery business Ex vivo Echocardiography Transesophageal MESH: Equipment Design |
| Zdroj: | Ultrasound in Medicine & Biology Ultrasound in Medicine & Biology, Elsevier, 2003, 29 (2), pp.285-91. ⟨10.1016/S0301-5629(02)00701-9⟩ |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/S0301-5629(02)00701-9⟩ |
| Popis: | New curative and palliative treatments must be proposed in order to respond to the bad long-term prognosis of esophageal cancers. It has been demonstrated that High Intensity Ultrasound (HIU) can induce rapid, complete and well-defined coagulation necrosis. For the treatment of this cancer, we designed an applicator that uses an intraductal approach. The active part is an air-backed plane transducer. It has an external water-cooling system and operates at 10 MHz. Ex vivo experiments conducted on pig liver demonstrated the ability of this applicator to generate, by rotating the transducer, circular or sector-based coagulation necroses at predetermined depths up to 13 mm with an excellent angular precision. The treatment of sector-based esophageal tumour may be critical where both malignant and healthy tissues are covered by the ultrasound beam. Thus, in vivo trials were conducted on five healthy pig esophaguses in order to determine the maximal thermal dose that will not induce a perforation of the esophagus or surrounding tissues. From the results of previous studies, this dose is high enough in order to treat pathological tissues. These promising results indicate that this ultrasound system represents a safe and effective tool for the clinical treatment of esophageal tumours. |
| Databáze: | OpenAIRE |
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