Genetic and molecular diversity in nondeletion Hb H disease
| Autor: | M G Hadjiminas, B. Aldridge, David J. Weatherall, Doug Higgs, J. B. Clegg, Antonio Cao, C Kattamis, L. Pressley, E A Rachmilewitz, A Metaxatou-Mavromati, T Sophocleous |
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| Rok vydání: | 1981 |
| Předmět: |
Genetics
Messenger RNA Multidisciplinary Hemoglobin H Genetic Linkage Hemoglobins Abnormal Haplotype RNA Chromosome Mapping DNA Restriction Enzymes Biology Molecular Weight Restriction enzyme Genes Genetic linkage hemic and lymphatic diseases Genes Regulator Hb h disease Humans Thalassemia RNA Messenger Globin gene Chromosome Deletion Gene Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 78(9) |
| ISSN: | 0027-8424 |
| Popis: | Restriction endonuclease mapping of nondeletion alpha-thalassemia determinants from a variety of racial groups showed no detectable abnormalities within a 40-kilobase region of the zeta-alpha globin gene cluster. By using a zeta-specific probe, we defined three different types of interactions that give rise to Hb H disease, each involving a nondeletion alpha-thalassemia haplotype. mRNA analysis showed further diversity within these groups, indicating that there are at least three nondeletion determinations. |
| Databáze: | OpenAIRE |
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