Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests
| Autor: | Marco Bonomi, Giovanni Vitale, Leila Danesi, Giacomo Gazzano, Letizia Maria Fatti, Biagio Cangiano, Luisa Gilardini, Chiara Francesca Caparello, Antonio Conti, Luca Persani, Marina Croci, Marco Stramba-Badiale, Iacopo Chiodini, Stefania Bonadonna |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging hydroxychloroquine Activities of daily living Coronavirus disease 2019 (COVID-19) serology 030209 endocrinology & metabolism Sensitivity and Specificity Correlation 03 medical and health sciences Sex Factors 0302 clinical medicine Activities of Daily Living Pandemic Humans Medicine 030212 general & internal medicine Mortality Vitamin D Pandemics Aged Aged 80 and over Vitamin d supplementation SARS-CoV-2 business.industry Tinetti test Age Factors COVID-19 Cell Biology Middle Aged nasopharyngeal swab Nursing Homes Italy Dietary Supplements Female Observational study business Nursing homes Research Paper Demography |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.202307 |
| Popis: | Introduction: The COVID-19 pandemic caused an increased mortality in nursing homes due to its quick spread and the age-related high lethality. Results: We observed a two-month mortality of 40%, compared to 6.4% in the previous year. This increase was seen in both COVID-19 positive (43%) and negative (24%) residents, but 8 patients among those testing negative on the swab, tested positive on serological tests. Increased mortality was associated with male gender, older age, no previous vitamin D supplementation and worse “activities of daily living (ADL)” scores, such as Barthel index, Tinetti scale and S.OS.I.A. classification. Conclusion: Our data confirms a higher geriatric mortality due to COVID-19. Negative residents also had higher mortality, which we suspect is secondary to preanalytical error and a low sensitivity of the swab test in poorly compliant subjects. Male gender, older age and low scores on ADL scales (probably due to immobility) are risk factors for COVID-19 related mortality. Finally, mortality was inversely associated with vitamin D supplementation. Design: In this observational study, we described the two-month mortality among the 157 residents (age 60-100) of a nursing home after Sars-CoV-2 spreading, reporting the factors associated with the outcome. We also compared the diagnostic tests for Sars-CoV-2. |
| Databáze: | OpenAIRE |
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