Curvulin and Phaeosphaeride A from Paraphoma sp. VIZR 1.46 Isolated from Cirsium arvense as Potential Herbicides
| Autor: | Alexander Berestetskiy, Leonid Chisty, Antonio Evidente, S. V. Sokornova, Yuriy Tokarev, Ekaterina V. Poluektova |
|---|---|
| Přispěvatelé: | Poluektova, Ekaterina, Tokarev, Yuriy, Sokornova, Sofia, Chisty, Leonid, Evidente, Antonio, Berestetskiy, Alexander |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
curvulin Pharmaceutical Science Plant Weeds 01 natural sciences Cirsium Article Analytical Chemistry lcsh:QD241-441 phytotoxins Phytotoxin lcsh:Organic chemistry Ascomycota Drug Discovery Botany Bioassay Physical and Theoretical Chemistry Cirsium arvense Pathogen Paramecia Plant Weed biology Dose-Response Relationship Drug Molecular Structure phaeosphaeride A 010405 organic chemistry Chemistry Herbicides Drug Discovery3003 Pharmaceutical Science Organic Chemistry Pesticide Antimicrobial biology.organism_classification Bridged Bicyclo Compounds Heterocyclic 0104 chemical sciences Paraphoma sp. VIZR 1.46 Chemistry (miscellaneous) herbicidal potential Molecular Medicine Phytotoxicity Herbicide Bacteria 010606 plant biology & botany |
| Zdroj: | Molecules Volume 23 Issue 11 Molecules, Vol 23, Iss 11, p 2795 (2018) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules23112795 |
| Popis: | Phoma-like fungi are known as producers of diverse spectrum of secondary metabolites, including phytotoxins. Our bioassays had shown that extracts of Paraphoma sp. VIZR 1.46, a pathogen of Cirsium arvense, are phytotoxic. In this study, two phytotoxically active metabolites were isolated from Paraphoma sp. VIZR 1.46 liquid and solid cultures and identified as curvulin and phaeosphaeride A, respectively. The latter is reported also for the first time as a fungal phytotoxic product with potential herbicidal activity. Both metabolites were assayed for phytotoxic, antimicrobial and zootoxic activities. Curvulin and phaeosphaeride A were tested on weedy and agrarian plants, fungi, Gram-positive and Gram-negative bacteria, and on paramecia. Curvulin was shown to be weakly phytotoxic, while phaeosphaeride A caused severe necrotic lesions on all the tested plants. To evaluate phaeosphaeride A&rsquo s herbicidal efficacy, the phytotoxic activity of this compound in combination with five different adjuvants was studied. Hasten at 0.1% (v/v) was found to be the most potent and compatible adjuvant, and its combination with 0.5% (v/v) semi-purified extract of Paraphoma sp. VIZR 1.46 solid culture exhibited maximum damage to C. arvense plants. These findings may offer significant importance for further investigation of herbicidal potential of phaeosphaeride A and possibly in devising new herbicide of natural origin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |