Chronic nicotine reverses age-associated increases in tail-flick latency and anxiety in rats
| Autor: | Chandan Prasad, Jeffrey W. Brock, Emmanuel S. Onaivi, Anwar Hamdi, Shakeel Faroouqui, Shorye Payne |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pain Threshold Senescence Aging Nicotine medicine.medical_specialty Time Factors Anxiety General Biochemistry Genetics and Molecular Biology Latency Period (Psychology) Internal medicine Threshold of pain medicine Animals General Pharmacology Toxicology and Pharmaceutics Young adult Pain Measurement Behavior Animal Dose-Response Relationship Drug business.industry Latency Period Psychological General Medicine Rats Inbred F344 Rats Dose–response relationship Endocrinology Nociception Latency stage Anesthesia business medicine.drug |
| Zdroj: | Life Sciences. 54:193-202 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(94)00588-5 |
| Popis: | The chronic consumption of low doses of nicotine in drinking water for two years consistently increased the sensitivity of rats to a nociceptive thermal stimulus (tail-flick test), but reduced aversiveness in the elevated plus-maze test, relative to the responses of age-matched controls in these tests. The responses of aged nicotine-consuming rats were indistinguishable from those of young adult rats that did not receive nicotine. To determine whether these effects were due to a nicotine-induced retardation of age-related changes, young adult rats were similarly treated with nicotine for three months and similar changes in the tail-flick latency and performance in the plus-maze test were observed during nicotine consumption. These changes were reversed following withdrawal from nicotine. It is concluded that the maintenance of circulating low levels of nicotine (and/or its metabolites) increased the nociceptive sensitivity of the rats and reduced their aversions in the plus-maze test regardless of their age. |
| Databáze: | OpenAIRE |
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