A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application
| Autor: | Jovana S. Vuković, Marija M. Babić, Aleksandra A. Perić-Grujić, Simonida Lj. Tomić, Katarina M. Antić, Miona G. Miljković, Jovanka M. Filipović |
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| Rok vydání: | 2015 |
| Předmět: |
Thermal properties
Materials science Polymers chemistry.chemical_element macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials chemistry.chemical_compound Differential scanning calorimetry Polymer chemistry medicine General Materials Science Itaconic acid Fourier transform infrared spectroscopy Acrylate technology industry and agriculture 021001 nanoscience & nanotechnology Condensed Matter Physics Copper 0104 chemical sciences chemistry Transport properties Self-healing hydrogels Swelling medicine.symptom 0210 nano-technology Glass transition Nuclear chemistry |
| Zdroj: | Materials Chemistry and Physics |
| ISSN: | 0254-0584 |
| DOI: | 10.1016/j.matchemphys.2015.08.022 |
| Popis: | In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed. |
| Databáze: | OpenAIRE |
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