Prostaglandin-Endoperoxide Synthase 2 (PTGS2) in the Oviduct: Roles in Fertilization and Early Embryo Development
| Autor: | Wipawee Winuthayanon, Prashanth Anamthathmakula |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty animal structures medicine.medical_treatment Uterus Embryonic Development Biology 03 medical and health sciences 0302 clinical medicine Endocrinology Human fertilization Capacitation Internal medicine medicine Animals Humans Fallopian Tubes Mini-Reviews 030219 obstetrics & reproductive medicine Assisted reproductive technology urogenital system Ovary Embryogenesis Decidualization Embryo transfer Cell biology 030104 developmental biology medicine.anatomical_structure Cyclooxygenase 2 Fertilization Prostaglandins Oviduct Female |
| Zdroj: | Endocrinology |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endocr/bqab025 |
| Popis: | The mammalian oviduct is a dynamic organ where important events such as final maturation of oocytes, transport of gametes, sperm capacitation, fertilization, embryo development, and transport take place. Prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase 2 (COX-2), is the rate-limiting enzyme in the production of prostaglandins (PGs) and plays an essential role during early pregnancy, including ovulation, fertilization, implantation, and decidualization. Even though the maternal-embryo communication originates in the oviduct, not many studies have systemically investigated PTGS2 signaling during early development. Most of the studies investigating implantation and decidualization processes in Ptgs2-/- mice employed embryo transfer into the uterus, thereby bypassing the mammalian oviduct. Consequently, an understanding of the mechanistic action as well as the regulation of PTGS2 and derived PGs in oviductal functions is far from complete. In this review, we aim to focus on the importance of PTGS2 and associated PGs signaling in the oviduct particularly in humans, farm animals, and laboratory rodents to provide a broad perspective to guide further research in this field. Specifically, we review the role of PTGS2-derived PGs in fertilization, embryo development, and transport. We focus on the actions of ovarian steroid hormones on PTGS2 regulation in the oviduct. Understanding of cellular PTGS2 function during early embryo development and transport in the oviduct will be an important step toward a better understanding of reproduction and may have potential implication in the assisted reproductive technology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|