Effects of repeated intra-articular hyaluronic acid on cartilage degeneration evaluated by T1ρ mapping in knee osteoarthritis
| Autor: | Atsuya Watanabe, Hiroshi Watanabe, Yasushi Oshima, Shinji Kiuchi, Futoshi Ikuta, Sanshiro Hashimoto, Kenji Takahashi, Tomoyuki Okuaki |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Cartilage Articular Male musculoskeletal diseases Pathology medicine.medical_specialty 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Osteoarthritis Body Mass Index Injections Intra-Articular T1ρ mapping chemistry.chemical_compound Intra articular Rheumatology Hyaluronic acid medicine Humans Hyaluronic Acid Cartilage degeneration Retrospective Studies medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged Osteoarthritis Knee musculoskeletal system medicine.disease Magnetic Resonance Imaging chemistry business human activities |
| Zdroj: | Modern Rheumatology. 31:912-918 |
| ISSN: | 1439-7609 1439-7595 |
| DOI: | 10.1080/14397595.2020.1830483 |
| Popis: | Intra-articular injection of hyaluronic acid (IAHA) has been used for the treatment of knee osteoarthritis (OA), but its effectiveness remains controversial. This study analyzed knee OA over time by magnetic resonance imaging (MRI) T1ρ mapping to objectively evaluate whether long-term repeated administration of IAHA influences cartilage degeneration.Sixty knees of 60 patients [58.3 ± 12.5 years (mean ± standard deviation)] who had multiple T1ρ mapping images were retrospectively analyzed. We calculated the T1ρ values of the medial femorotibial cartilage and classified changes in degenerative areas over time into 3 groups: Improvement, No Change, and Deterioration.Average time between 2 MRI scans was 7.6 ± 1.2 months. The number of IAHA administrations was 15.5 ± 21.3, 8.39 ± 7.19, and 5.80 ± 7.49 in the Improvement, No Change, and Deterioration groups, respectively. Body mass index and number of IAHA administrations were significant factors causing change in the area of degeneration (Cartilage degeneration may be improved with a higher number of administrations of IAHA, based on T1ρ mapping results. This highlights the possibility of increased treatment effectiveness of IAHA for knee OA with repeated administrations. |
| Databáze: | OpenAIRE |
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