Further Studies of the Norditerpene (+)-Harringtonolide Isolated fromCephalotaxus harringtoniavar.drupacea: Absolute Configuration, Cytotoxic and Antifungal Activities
| Autor: | Bastien Nay, Akino Jossang, Julie Nguyen-Pouplin, Bernard Bodo, Diane Delaroche, Laurent Evanno, Patrick Herson, Mannan Seuleiman |
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| Rok vydání: | 2008 |
| Předmět: |
Harringtonines
Antifungal Agents Stereochemistry Molecular Conformation Pharmaceutical Science Biology Pharmacognosy Cephalotaxus Analytical Chemistry chemistry.chemical_compound Cell Line Tumor Drug Discovery Humans Organic chemistry Pharmacology Organic Chemistry Absolute configuration biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid Cephalotaxaceae Complementary and alternative medicine chemistry Molecular Medicine Diterpene Tropone |
| Zdroj: | Planta Medica. 74:870-872 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2008-1074546 |
| Popis: | Harringtonolide (= hainanolide) is a complex polycyclic fused norditerpene isolated from CEPHALOTAXUS HARRINGTONIA var. DRUPACEA. In spite of its appealing biological properties - we measured an IC (50) of 43 nM on KB cells and a significant antifungal activity - its absolute configuration has not yet been firmly established. This was done herein using X-ray anomalous scattering after bromination of the tropone ring, unambiguously giving the stereochemistry 5 R,6 R,7 S,13 S,14 S,15 R,16 R. Detailed IN VITRO biological measurements are provided. |
| Databáze: | OpenAIRE |
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