Metal-Ion Selectivity of Chemically Modified Uracil Pairs in DNA Duplexes
| Autor: | Yoko Miyake, Yuko Watanabe, Akira Ono, Kenji Iwamoto, Itaru Okamoto |
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| Rok vydání: | 2009 |
| Předmět: |
Ions
Spectrometry Mass Electrospray Ionization Metal ions in aqueous solution Inorganic chemistry Uracil Bioinorganic chemistry General Chemistry DNA General Medicine Hydrogen-Ion Concentration Combinatorial chemistry Catalysis Nucleobase Ion Metal chemistry.chemical_compound chemistry Metals visual_art visual_art.visual_art_medium Transition Temperature heterocyclic compounds Selectivity |
| Zdroj: | Angewandte Chemie. 121:1676-1679 |
| ISSN: | 1521-3757 0044-8249 |
| DOI: | 10.1002/ange.200804952 |
| Popis: | DNA duplexes containing 5-modified uracil pairs (5-bromo, 5-fluoro, and 5-cyanouracil) bind selectivity to metal ions. Their selectivity is sensitive to the pH value of the solution (see picture), as the acidities of the modified uracil bases vary according to the electron-withdrawing properties of the substituents. |
| Databáze: | OpenAIRE |
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